Effects of X-ray irradiation on the color changes of PM-355 and Makrofol DE 7-2 nuclear track detectors have been investigated. Samples from PM-355 and Makrofol DE 7-2 polycarbonates were irradiated with X-ray doses at levels between 10 and 250 kGy. The transmission of these samples in the wavelength range 370–780 nm, as well as any color changes, was studied. The Commission International de E’Claire (CIE units x, y and z) methodology was used in this work for the description of colored samples. The color differences between the non-irradiated sample and those irradiated with different X-ray doses were calculated. The results indicate that both PM-355 and Makrofol DE 7-2 detectors acquire color changes under X-ray irradiation, but the PM-355 detector has more response to color change than that of Makrofol DE 7-2.